Xelmet 850 

Presentation:Xelmet 850 Tablet contains Metformin Hydrochloride BP 850 mg as the active pharmaceutical ingredient.It is presented as a film-coated tablet and is available in blister packs.

Indications: Xelmet 850 is indicated for the treatment of type 2 diabetes mellitus, particularly in overweight patients, when dietary management and exercise alone do not result in adequate glycemic control.In adults, it may be used as monotherapy or in combination with other oral antidiabetic agents or with insulin.In children from 10 years of age and adolescents,it may be used as monotherapy or in combination with insulin.A reduction of diabetic complications has been shown in overweight type 2 diabetic adult patients treated with metformin as first-line therapy after diet failure.  

Dosage and Administration: The dosage of Xelmet 850 must be individualized based on both effectiveness and tolerance, while not exceeding the maximum recommended daily doses.It should be administered orally with meals to reduce gastrointestinal side effects.

• Adults:The usual starting dose is 500 mg twice a day or 850 mg once a day, given with meals.Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per day, given in divided doses. For thoserequiring additional glycemic control, the maximum daily dose can be 2550 mg per day, usually given three times a day with meals.
• Children (over 10 years and adolescents):The usual starting dose is 500 mg twice a day, given with meals. Dosage increases should be made in increments of 500 mg weekly up toa maximum of 2000 mg per day, given in divided doses.  

Renal function should be assessed before initiating treatment and at least annually thereafter. Xelmet 850 is contraindicated in patients with an eGFR below 30 mL/min/1.73 m².  

Side Effects:Common side effects associated with Xelmet 850 may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite.A metallic taste may also occur. These side effects are often transient and may decrease over time. Long-term use of metformin may lead to vitamin B12 deficiency.Lactic acidosis is a rare but serious potential side effect.  

Precautions:Xelmet 850 is contraindicated in patients with hypersensitivity to metformin, severe renal failure (eGFR < 30 mL/min/1.73 m²), any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis), and acute conditions with the potential to alter renal function (e.g., dehydration, severe infection, shock).Caution should be exercised in patients with conditions that may cause tissue hypoxia (e.g., cardiac or respiratory failure, recent myocardial infarction), hepatic insufficiency, and acute alcohol intoxication.

Storage: Store Xelmet 850 tablets below 30°C. Protect from light and moisture. Keep out of the reach of children. Do not use after the expiry date.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.