Indications: Toza (Nitazoxanide) is an antiprotozoal agent indicated for the treatment of diarrhea caused by:

• Cryptosporidium parvum
• Giardia lamblia
• Entamoeba histolytica

Dosage and Administration: Toza is recommended to be administered with food. The dosage depends on the age of the patient and the formulation used.

• Tablet (500 mg):
  • Adults and children 12 years or above: 1 tablet (500 mg) every 12 hours for 3 days.
• Suspension (100 mg/5 ml):
  • Children 1-3 years: 5 ml (1 teaspoonful) every 12 hours for 3 days.
  • Children 4-11 years: 10 ml (2 teaspoonfuls) every 12 hours for 3 days.
  • Adults and children 12 years or above: 25 ml (5 teaspoonfuls) every 12 hours for 3 days.

Side Effects: The most frequent side effects reported with Toza are abdominal pain, vomiting, and headache. These side effects are typically mild and transient. Very rare side effects may include nausea, anorexia, flatulence, increased appetite, enlarged salivary glands, increased creatinine and SGPT levels, pruritus, rhinitis, sweating, dizziness, and discolored urine.

Precautions: Toza (Nitazoxanide) is contraindicated in patients with known hypersensitivity to nitazoxanide or any components of the preparation. Caution should be exercised when administering Toza concurrently with other highly plasma protein-bound drugs with a narrow therapeutic index. Toza should be administered with caution to patients with hepatic and biliary disease and to patients with renal disease.

Use in Pregnancy and Lactation: The US FDA pregnancy category for Nitazoxanide is B. It should be used during pregnancy only if clearly needed. Nitazoxanide has been shown to be excreted in human milk, so caution should be exercised when administered during lactation.

Storage: Keep in a dry place away from light and heat. Keep out of the reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.