Thyzol 10 

Presentation: Each tablet of Thyzol 10 contains 10 mg of Methimazole. It is available in strips. The tablets have specific shapes and markings depending on the manufacturer in Bangladesh (Nuvista Pharma Ltd.).

Indications: Thyzol (methimazole) is indicated for the treatment of hyperthyroidism (overactive thyroid gland), including:

• Graves' disease.
• Toxic multinodular goiter. For patients for whom surgery or radioactive iodine therapy is not an appropriate treatment option. Thyzol is also used to ameliorate symptoms of hyperthyroidism in preparation for thyroidectomy or radioactive iodine therapy.  

Dosage and Administration:  The total daily dosage is usually given in 3 divided doses at approximately 8-hour intervals.  

• Adults:The initial daily dosagefor hyperthyroidism is usually 15 mg for mild, 30 to 40 mg for moderately severe, and 60 mg for severe conditions, divided into three doses. The maintenance dosage is usually 5 to 15 mg daily.
• Children and Adolescents (3 to 17 years): The initial daily dose is usually 0.5 mg/kg body weight, divided into 2 or 3 doses. The maintenance dose is adjusted based on the patient's response. The maximum daily dose is 40 mg.
• Thyzol tablets are taken orally at the same time each day with regard to meals, as food may affect absorption unpredictably. Follow your doctor's specific instructions.

Side Effects: Common side effects may include skin rash, urticaria, nausea, vomiting, epigastric distress, arthralgia, paresthesia, loss of taste, abnormal loss of hair, myalgia, headache, pruritus, drowsiness, neuritis, edema, vertigo, skin pigmentation, jaundice, sialadenopathy, and lymphadenopathy.Less common but serious side effects can include agranulocytosis, granulocytopenia, thrombocytopenia, aplastic anemia, drug fever, a lupus-like syndrome, insulin autoimmune syndrome (which canresult in hypoglycemic coma), hepatitis,periarteritis, and hypoprothrombinemia.

Precautions: Thyzol (methimazole) is contraindicated in patients with known hypersensitivity to methimazole or other thionamide derivatives. It readily crosses placental membranes and can cause fetal harm, particularly when administered in the first trimester of pregnancy.Patients should immediately report any symptoms suggestive of agranulocytosis, such as fever or sore throat. Liver toxicity and hypothyroidism can occur. Thyroid function tests should be monitored periodically during therapy. Concurrent use with anticoagulants (oral) may increase their activity. Beta-adrenergic blocking agents may require dose reduction as the patient becomes euthyroid.

Storage: Store in a cool (below 30°C) and dry place, away from light and children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.