Tegretol CR 200

Presentation: Each controlled-release tablet contains Carbamazepine BP 200 mg. 

Indications: Tegretol CR is indicated for the treatment of:

• Epilepsy: Partial seizures with complex symptomatology (psychomotor, temporal lobe), generalized tonic-clonic seizures (grand mal), mixed seizure patterns,¹and other partial or generalized seizures. It is not usually effective in absence seizures (petit mal).
• Trigeminal Neuralgia: For the relief of pain associated with true trigeminal neuralgia.
• Bipolar Disorder: For the treatment of manic and mixed episodes of bipolar I disorder and as maintenance therapy to prevent or diminish the intensity of subsequent episodes in patients with bipolar disorder.

Dosage and Administration: Dosage must be individualized by the physician. Initiate treatment at the lowest effective dose.

• Epilepsy:
  • Adults and Adolescents over 12 years: Usually start with 200 mg twice daily. Dosage is gradually increased until seizure control is achieved, typically to 800-1200 mg daily in two divided doses.
  • Children (4-12 years): Usually start with 100 mg twice daily. Dosage is gradually increased to 400-800 mg daily in two divided doses.
• Trigeminal Neuralgia: Usual initial dose is 200 mg twice daily. Dosage is gradually increased until pain relief is achieved, usually to 400-800 mg daily in two divided doses. Maximum recommended dose is 1200 mg daily.
• Bipolar Disorder: Usual initial dose is 200 mg twice daily. Dosage is gradually increased until a therapeutic level is achieved, usually within the range of 400-1600 mg daily in divided doses.

Tegretol CR tablets are controlled-release and should be swallowed whole; they should not be crushed or chewed. They can be taken with or without food. When converting from immediate-release carbamazepine to Tegretol CR, the total daily dose should generally be maintained.

Side Effects: Very common side effects include dizziness, ataxia, somnolence, fatigue, diplopia, nausea, and vomiting. Common side effects include headache, dry mouth, blurred vision, accommodation disorder, and skin rash. Serious side effects can include blood dyscrasias (e.g., agranulocytosis, aplastic anemia), Stevens-Johnson syndrome, toxic epidermal necrolysis, and liver damage.

Precautions: Before starting Tegretol CR, inform your physician about any history of bone marrow depression, active hepatic disease, serious cardiovascular disease, or hypersensitivity to carbamazepine or structurally related compounds (e.g., tricyclic antidepressants). Genetic testing for HLA-B*1502 allele is recommended in patients with ancestry in genetically at-risk populations (e.g., Asian). Carbamazepine can interact with many other drugs, including other antiepileileptics, oral contraceptives, anticoagulants, and certain antibiotics. Inform your physician about all medications you are taking. May increase the risk of suicidal thoughts or behavior. Avoid abrupt discontinuation. Use with caution during pregnancy and breastfeeding.

Storage: Store below 30°C in a dry place, protected from light. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.