Sitacret M 500 

Presentation: Each film-coated tablet of Sitacret M 500 contains Sitagliptin Phosphate Monohydrate INN equivalent to Sitagliptin 50 mg and Metformin Hydrochloride BP 500 mg. It is available in strips. 

Indications: Sitacret M is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate.

Dosage and Administration: The dosage should be individualized based on the patient's current regimen, effectiveness, and tolerability, not exceeding the maximum recommended daily dose of sitagliptin 100 mg and metformin 2000 mg. Generally administered twice daily with meals. Initiate with lower doses to minimize gastrointestinal side effects of metformin.

• Starting dose in metformin-naïve patients: Usually 50 mg sitagliptin/500 mg metformin hydrochloride twice daily.
• Switching from metformin: Start with Sitacret M containing 50 mg sitagliptin twice daily and the current metformin dose.
• For patients on metformin 850 mg twice daily, the starting dose is 50 mg sitagliptin/1000 mg metformin hydrochloride twice daily.
• Swallow whole with water; do not crush or chew.

Side Effects: Common side effects may include diarrhea, nausea, vomiting, upset stomach, and headache. Hypoglycemia may occur when used with insulin or sulfonylureas. Other possible side effects include nasopharyngitis and abdominal pain.

Precautions: Contraindicated in severe renal impairment (eGFR < 30 mL/min/1.73 m²), acute or chronic metabolic acidosis (including diabetic ketoacidosis), or known hypersensitivity to sitagliptin or metformin. Not recommended in moderate renal impairment (eGFR 30-45 mL/min/1.73 m²) unless benefits outweigh risks. Assess renal function before initiation and annually thereafter. Avoid in hepatic disease and excessive alcohol intake. Discontinue if pancreatitis is suspected.

Storage: Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.