Renapine XR 200 Tablet

Generic Name: Quetiapine 

Strength: 200mg

Presentation: Extended-Release Tablet

Description:

Renapine XR contains Quetiapine Fumarate, an atypical antipsychotic medication. It works by affecting multiple neurotransmitters in the brain, including serotonin and dopamine. Renapine XR is formulated for extended release, providing a once-daily dosage.

Indications:

Renapine XR is indicated for the treatment of:

• Acute and chronic psychoses, including schizophrenia

• Bipolar disorder, including:

  • Manic episodes associated with bipolar disorder

  • Depressive episodes associated with bipolar disorder

  • Maintenance treatment of bipolar I disorder in combination with mood stabilizers

Dosage and Administration:

• Renapine XR is administered once daily.

• The dosage varies depending on the specific condition and individual patient response.

  • Schizophrenia: The total daily dose for the first four days of therapy is 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3), and 300 mg (Day 4). From Day 4 onwards, the dose should be titrated to the usual effective dose range of 300-450 mg/day.

  • Manic episodes associated with bipolar disorder: The total daily dose for the first four days of therapy is 100 mg (Day 1), 200 mg (Day 2), 300 mg (Day 3), and 400 mg (Day 4). Further dosage adjustments up to 800mg/day by Day 6 should be in increments of no greater than 200 mg/day.

  • Depressive episodes associated with bipolar disorder: The daily dose for the first four days of therapy is 50 mg (Day 1), 100 mg (Day 2), 200 mg (Day 3) and 300 mg (Day 4). Quetiapine can be titrated to 400 mg on Day 5 and up to 600mg by Day 8.

• It is recommended to swallow the tablet whole. Do not crush, chew, or divide.

• Renapine XR can be taken with or without food.

Contraindications:

• Hypersensitivity to quetiapine or any component of the formulation.

Precautions:

• Use with caution in patients with known cardiovascular disease, cerebrovascular disease, or other conditions predisposing to hypotension.

• Renapine XR may induce orthostatic hypotension, especially during the initial dose-titration period.

• Caution is recommended when treating patients with a history of seizures.

• If signs and symptoms of tardive dyskinesia appear, dose reduction or discontinuation of Renapine XR should be considered.

• As with other antipsychotics, caution should be exercised when prescribing Renapine XR in patients with cardiovascular disease or a family history of QT prolongation.

• Severe neutropenia has been uncommonly reported in clinical trials.

• Increases in blood glucose and hyperglycemia, and occasional reports of diabetes, have been observed in clinical trials.

Side Effects:

The most commonly reported adverse drug reactions (ADRs) with Renapine XR are:

• Somnolence

• Dizziness

• Dry mouth

• Withdrawal (discontinuation) symptoms

• Elevations in serum triglyceride levels

• Elevations in total cholesterol (predominantly LDL cholesterol)

• Decreases in HDL cholesterol

• Weight gain

Remember:

• This information provides a general overview. Always consult your healthcare provider for specific instructions and advice regarding Renapine XR 200.

• Do not stop taking this medication without consulting your doctor.

• Report any unusual or severe side effects to your doctor immediately.