Oramet SR 1000

Presentation: Sustained-release tablets containing 1000 mg of metformin hydrochloride.

Indications: Oramet SR 1000 is an oral antidiabetic drug belonging to the biguanide class, formulated for sustained release. It is indicated for the treatment of type 2 diabetes mellitus, particularly in overweight patients, when dietary management and exercise alone do not result in adequate glycemic control.In adults, it can be used as monotherapy or in combination with other oral antidiabetic agents or with insulin.

Dosage and Administration: The usual starting dose of sustained-release metformin (including Oramet SR) is 500 mg once daily with the evening meal. The dose may be increased in increments of 500 mg weekly up to a maximum of 2000 mg once daily with the evening meal. If glycemic control is not achievedwith 2000 mg once daily, a dose of 1000 mg twice daily may be considered. Oramet SR 1000 tablets should be swallowed whole and should not be crushed, cut, or chewed. Take it with meals to reduce gastrointestinal side effects. Follow your doctor's instructions carefully.

Side Effects: Very common side effects include gastrointestinal disorders such as nausea, vomiting, diarrhea, abdominal pain, and loss of appetite. These usually occur at the start of therapy and resolve spontaneously in most cases. A slow increase in dose may improve gastrointestinal tolerability. A rare but serious side effect is lactic acidosis. Other possible side effects include taste disturbance and decreased vitamin B12 absorption with long-term use.

Precautions:

• Inform your doctor about any pre-existing medical conditions, especially kidney disease (eGFR < 30 mL/min is a contraindication), liver disease, heart failure, or any serious acute medical illness that can affect kidney function.
• Oramet SR is contraindicated in patients with acute metabolic acidosis (such as lactic acidosis or diabetic ketoacidosis).
• Temporary discontinuation of Oramet SR may be necessary before surgical procedures or radiological studies involving iodinated contrast agents.
• Excessive alcohol intake should be avoided while taking Oramet SR, as it can increase the risk of lactic acidosis.
• Inform your doctor if you are pregnant or breastfeeding. Management of diabetes during pregnancy should ideally be with insulin. Metformin is secreted in human breast milk, and a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importanceof the drug to the mother. 
• Beaware of potential drug interactions and inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
• Regular monitoring of renal function is advised. Annual estimation of vitamin B12 levels may be necessary during long-term use.

Storage: Store below 30°C, protected from moisture. Keep out of the reach of children.

Important Note: This information is for general knowledge and informational purposes only, and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.