Napgin 500mg provides anti-inflammatory and analgesic relief for:
✅ Chronic Inflammatory Conditions:

• Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis

• Gout attacks, juvenile idiopathic arthritis

• Bursitis, tendonitis

✅ Acute Pain Management:

• Migraines, dysmenorrhea (period pain)

• Post-operative pain, renal colic

• Musculoskeletal injuries, toothache

Mechanism of Action

Naproxen (propionic acid derivative) works by:

1. Dual COX Inhibition: Blocks both COX-1 & COX-2 enzymes → reduces prostaglandin synthesis

2. Triple Action:

   • Anti-inflammatory (reduces swelling)

   • Analgesic (pain relief)

   • Antipyretic (fever reduction)

Unlike paracetamol: Addresses inflammation but carries GI/CV risks

Dosage Guidelines

*Short-term use only. Always take with food.
*Renal impairment (CrCl <30mL/min): Contraindicated*

Critical Safety Alerts

❌ Absolute Contraindications:

• CABG surgery pain management

• 3rd trimester pregnancy (Category D)

• Severe renal/hepatic impairment

• NSAID hypersensitivity or aspirin-induced asthma

⚠️ High-Risk Monitoring Required:

• Cardiovascular: Hypertension, stroke history

• GI: Ulcers/bleeding history, elderly patients

• Hematologic: Coagulation disorders, anticoagulant use

Adverse Effects

Drug Interaction Highlights

Special Populations

• Pregnancy: Avoid 3rd trimester (premature ductus closure risk)

• Breastfeeding: Trace excretion → use shortest effective duration

• Elderly: Start at 50% dose (↑ GI/renal/CV risks)

• Alcohol Use: Absolute avoidance (↑ ulcer/bleeding risk)

Patient Safety Protocol

✔️ Essential Practices:

• Use lowest effective dose for shortest duration

• Report black stools/vomited blood immediately

• Monitor BP weekly during treatment

⚠️ Discontinue & Seek Help If:

• Vision/hearing changes

• Unexplained weight gain/swelling

• Chest/jaw pain or neurological symptoms

Storage & Handling

• Store below 30°C in original packaging

• Protect from moisture

• Keep secured away from children

Registered চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন
Not for pre-operative analgesia or fever management