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Moxaclav 375

In stock
৳142.50৳150.00

⛨ Tablet - (250mg+125mg) 
✅ 6 Tablets (1 Strip)

Estimated delivery:17 Jun - 20 Jun

SKU:

E-534

Categories:

Medicine
  • 100% Original Products

    100% Original Products

  • Fast Delivery within 24-72 Hours

    Fast Delivery within 24-72 Hours

  • Cash On Delivery Available

    Cash On Delivery Available

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    24/7 Order Support via whatsapp

Moxaclav treats bacterial infections at these sites:

  • Respiratory: Pneumonia, bronchitis, sinusitis, tonsillitis, otitis media

  • GU Tract: Cystitis, pyelonephritis, urethritis

  • Skin/Soft Tissue: Cellulitis, abscesses

  • Systemic Infections: Septic abortion, intra-abdominal sepsis, osteomyelitis

*Not for viral infections. Minimum effective duration: 5-7 days.*


Formulations & Strengths

FormulationAmoxicillinClavulanic AcidUse Case
Tablets250-875 mg125 mgAdults & >12 years
Suspension (5mL)125 mg31.25 mgChildren 1-12 years
Forte Suspension (5mL)400 mg57.5 mgSevere pediatric cases
IV Injection500-1000 mg100-200 mgHospital/severe cases

Mechanism of Action

  • Amoxicillin: Broad-spectrum penicillin → disrupts bacterial cell wall synthesis.

  • Clavulanate: β-lactamase inhibitor → protects amoxicillin from enzyme degradation.
    Synergy: Extends coverage to β-lactamase-producing strains of:

S. aureus, H. influenzae, E. coli, Klebsiella


Dosage Guide

Oral Therapy

Patient GroupStandard DoseSevere Infection
Adults625 mg 12-hourly OR 375 mg 8-hourly1g 12-hourly OR 625 mg 8-hourly
Children 7-12yForte: 5mL 12-hourlyForte: 10mL 12-hourly
Children 2-6yForte: 2.5mL 12-hourlyForte: 5mL 12-hourly
Infants <1y25 mg/kg/day (amox) in 3 divided doses

IV Therapy

Patient GroupStandard DoseSevere Infection
Adults1.2g 8-hourly1.2g 6-hourly
Children >3mo30 mg/kg 8-hourly30 mg/kg 6-hourly
Surgical Prophylaxis1.2g pre-op → 1.2g 8-hourly (high-risk)

Critical Administration Notes

  • Oral: Take at meal start to enhance absorption + reduce GI upset.

  • Suspension Prep:

    1. Shake powder bottle

    2. Add water to marked line

    3. Shake until dissolved → refrigerate (use within 7 days)

  • IV Injection:

    • Reconstitute with 20mL Water for Injection

    • Administer over 3-4 min IV push or 30-min infusion

    • Never mix with: Dextrose, blood products, bicarbonate solutions


Safety Profile

⚠️ Contraindications

  • Penicillin allergy (cross-sensitivity with cephalosporins)

  • History of drug-induced cholestatic jaundice

Common Side Effects

Diarrhea (15%), nausea (10%), vaginal candidiasis (8%), rash (5%)

Serious Risks

  • Clostridioides difficile colitis (watery/bloody stools)

  • Hepatotoxicity (monitor LFTs)

  • Anaphylaxis (have epinephrine available)


Drug Interactions

DrugEffectRecommendation
Allopurinol↑ Risk of skin rashAvoid concurrent use
Oral ContraceptivesReduced efficacyUse backup contraception
Warfarin↑ Bleeding risk (PT prolongation)Monitor INR closely

Special Populations

ConditionDosage Adjustment
Renal Impairment (CrCl <30 mL/min)375mg 12-hourly OR 1.2g IV → 0.6g IV 12-hourly
Hepatic ImpairmentAvoid in severe disease
Pregnancy (Category B)Use only if benefit > risk
BreastfeedingTrace amounts in milk → monitor infant for diarrhea

Overdose Management

Symptoms: Severe nausea, electrolyte imbalance, crystalluria
Treatment: Hemodialysis + supportive care


Storage & Stability

  • Tablets/Suspension: Below 25°C, protected from moisture

  • Reconstituted IV: Use within 20 minutes (discard unused portion)

  • Oral Suspension: Refrigerate (2-8°C) → discard after 7 days

Medical Notice: Always complete full course. Not for prophylaxis except surgical.
Registered চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন


 

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