Minium 10 Tabletcontains Flunarizine 10mg.  

Indications: Minium 10 is used for:

• Prophylaxis of classic (with aura) or common (without aura) migraine headaches.  
• Symptomatic treatment of vestibular vertigo (due to a diagnosed functional disorder of the vestibular system).  
• Peripheral Vascular Disease (PVD).  
• Motion sickness.  
• Refractory epilepsy resistant to conventional antiepileptic therapy (as add-on therapy). 

Dosage and Administration:

• Migraine Prophylaxis:
  • Starting dose for patients under 65 years: 10 mg at night.
  • Starting dose for patients over 65 years: 5 mg daily at night.
  • If depressive, extrapyramidal or other unacceptable symptoms occur, discontinue treatment.
  • If no significant improvement is observed after 2 months of initial treatment, discontinue treatment.
  • Maintenance treatment (if responding well): Reduce dose to 5 days of treatment at the same daily dose with two successive medicine-free days every week.
  • Even if prophylactic maintenance is successful and well-tolerated, interrupt after 6 months and re-initiate only if relapse occurs.
• Peripheral Vascular Disease:10 mg twice daily, up to 30 mg per day if required.  

Vertigo & Motion Sickness:10-20 mg daily for adults and 5 mg daily for children (> 40 kg).  

Epileptic Seizure(as add-on therapy): 15-20 mg daily in adults and 5 to 10 mg daily for children. 

Side Effects: Common side effects may include:

• Drowsiness and/or fatigue.
• Weight gain and/or increased appetite.  

Less common side effects may include:

• Depression (female patients with a history of depressive illness may be particularly at risk).
• Extrapyramidal symptoms (such as bradykinesia, rigidity, akathisia, orofacial dyskinesia, tremor), of which elderly patients appear to be more at risk. 
• Heartburn.  
• Nausea.  
• Gastralgia (stomach pain).  
• Insomnia.  
• Anxiety.  
• Galactorrhea (abnormal milk flow).Dry mouth.  
• Muscle ache.Skin rash.  

Contraindications: Minium 10 is contraindicated in patients with:

• Hypersensitivity to flunarizine.  
• A history of depressive illness.
• Pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders.  

Precautions:

• Flunarizine may cause drowsiness, which can be aggravated by alcohol or other CNS depressants. Patients should be cautioned against driving or operating machinery. 
• Minium 10 is not suitable for treating an acute migraine attack.
• This treatment may give rise to extrapyramidal and depressive symptoms and reveal Parkinsonism, especially in predisposed patients such as the elderly.  
• Use with caution in patients with epilepsy, cardiovascular disease, and glaucoma.

Drug Interactions:

• Galactorrhea has been reported in women on oral contraceptives within the first two months of flunarizine treatment.
• Hepatic enzyme inducers such as Carbamazepine and Phenytoin may increase the metabolism of flunarizine, potentially requiring a dosage increase. 
• Concomitant use of a calcium channel blocker and amiodarone has been reported to result in sinus arrest and atrioventricular block.  
• Excessive sedation can occur when alcohol, hypnotics, or tranquilizers are taken. 

Storage:Keep below 30°C temperature, away from light & moisture. Keep out of reach of children. 

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.