Metryl Suspension - (200mg/5ml)

Presentation: Each 5 ml of Metryl Suspension contains Metronidazole Benzoate BP equivalent to Metronidazole 200 mg. Available in bottles of 60 ml.  

Indications:Metryl (Metronidazole) is an antibiotic and antiprotozoal medication used to treat infections caused by bacteria and parasites. It is indicated for:  

• The prevention of post-operative infections due to anaerobic bacteria.  
• The treatment of septicaemia, bacteraemia, peritonitis, brain abscess, pelvic abscess, pelvic cellulitis, and post-operative wound infections caused by anaerobes.  
• Urogenital trichomoniasis.  
• Bacterial vaginosis (also known as non-specific vaginitis).  
• All forms of amoebiasis (intestinal, extra-intestinal disease, and that of symptomless cyst passers).  
• Giardiasis.  
• Acute ulcerative gingivitis.  
• Anaerobically infected leg ulcers and pressure sores.  
• Acute dental infections due to anaerobic organisms.  
• Antibiotic-associated pseudomembranous colitis.  
• In combination with other medications for the eradication of Helicobacter pylori.

Dosage and Administration:Dosage depends on the condition being treated and the age and weight of the patient.Always follow your doctor's prescription.  

• Adults: Dosage varies widely depending on the infection. Examples include:
  • Trichomoniasis: 200 mg three times daily for 7 days, or 400 mg twice daily for 7 days, or a single dose of 2 g.
  • Amoebiasis: 400-800 mg three times daily for 5-10 days.
  • Giardiasis: 2 g once daily for 3 days or 400 mg three times daily for 5-7 days.
• Children:Dosage is usually based on body weight. Examples include:   
  • Amoebiasis:
    • Children 1-3 years: 50 mg three times daily.
    • Children 3-7 years: 100 mg twice daily.
    • Children 7-10 years: 100 mg three times daily.
  • Giardiasis: 15 mg/kg/day in three divided doses for 5-7 days.
  • For anaerobic infections in children, the usual dose is 7.5 mg/kg every 8 hours.  
• Metryl Suspension should be taken orally, usually after meals. Shake the bottle well before each use.  

Pharmacology: Metronidazole is a nitroimidazole antibiotic and antiprotozoal agent. It works by being taken up by anaerobic bacteria and protozoa, where its nitro group is reduced, forming reactive compounds that damage the pathogen's DNA, leading to cell death.

Side Effects: Common side effects may include:

• Nausea
• Vomiting
• Diarrhoea
• Metallic taste
• Headache
• Darkening of urine

Less common or serious side effects can occur. Consult your doctor immediately if you experience any severe or persistent side effects.

Precautions:

• Avoid alcohol consumption during treatment and for at least 48 hours after stopping Metryl, as it may cause a disulfiram-like reaction (nausea, vomiting, flushing, abdominal cramps).  
• Use with caution in patients with liver disease or central nervous system disorders.
• Metryl may darken urine.  
• Inform your doctor about any kidney disease.
• Metryl can interact with other medications, such as warfarin and lithium. Inform your doctor about all the medicines you are taking.  

Pregnancy & Lactation: Metryl should be used during pregnancy only if clearly needed. Some guidelines suggest avoiding it in the first trimester. Metronidazole passes into breast milk. Breastfeeding is usually not recommended during treatment and for a period after stopping the medication. Consult your doctor.  

Storage: Store below 30°C, protected from light. Keep out of the reach of children.

Therapeutic Class: Amoebicides, Antibiotics (Nitroimidazoles), Antiprotozoals.

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.