Indications & Clinical Uses

Maczith (Azithromycin) effectively treats bacterial infections caused by susceptible organisms, including:

• Respiratory Tract Infections: Pneumonia, bronchitis, sinusitis, pharyngitis/tonsillitis, otitis media

• Skin & Soft Tissue Infections

• Sexually Transmitted Infections: Non-gonococcal urethritis and cervicitis (Chlamydia trachomatis)

Pharmacology & Mechanism

• Targeted Delivery: High phagocyte concentration enables active transport to infection sites, achieving tissue levels >50x plasma concentrations.

• Unique Pharmacokinetics:

  • Acid-stable formulation for optimal oral absorption (best on empty stomach)

  • Extended half-life (68 hours) supports once-daily dosing

  • Biliary excretion (primarily unchanged drug)

• Microbial Action: Binds to 50S ribosomal subunit, inhibiting protein synthesis in susceptible strains.

Effective Against:

Dosage Regimens

Oral Administration:

IV Infusion (Adults Only):

• Community-acquired pneumonia: 500 mg IV daily × ≥2 days → switch to oral 500 mg to complete 7-10 days

• Pelvic inflammatory disease: 500 mg IV daily × 1-2 days → oral 250 mg to complete 7 days (add anaerobic coverage if suspected)

Administration Guidance

1. Suspension Preparation:

   • Shake bottle → add cooled boiled water to marked line → shake until fully dissolved

2. Timing: Take 1 hour before or 2 hours after meals/antacids

Drug Interactions

Safety Profile

Contraindications:

• Hypersensitivity to macrolides

• Hepatic impairment

• Concurrent ergot derivatives

Common Side Effects (Typically mild/moderate):

Gastrointestinal (nausea, diarrhea, abdominal pain), rash, reversible transaminase elevation

Serious Reactions (Rare):

• Angioedema, anaphylaxis, cholestatic jaundice, hearing loss (high-dose/long-term)

Special Populations

• Pregnancy (Category B): Use only if alternatives inadequate

• Lactation: Caution advised (excretion unknown)

• Renal Impairment: No adjustment if CrCl >40 mL/min; caution if severe impairment

• Hepatic Impairment: Avoid use (primary excretion route)

Overdose Management

Symptoms: Hearing loss, severe GI distress
Treatment: Gastric lavage + supportive care

Therapeutic Class

Macrolide Antibiotic

Storage & Handling

• Store below 30°C in original packaging

• Protect from light/moisture

• Keep out of children’s reach

Medical Notice: Always use under supervision of a registered physician. Dosage may vary based on infection severity and patient response.