Indications

Fuclav is indicated for the treatment of various bacterial infections, including:

• Pharyngitis/Tonsillitis
• Acute Bacterial Otitis Media
• Acute Bacterial Maxillary Sinusitis
• Lower respiratory tract infections (pneumonia, bronchitis)
• Uncomplicated skin and skin-structure infections
• Uncomplicated urinary tract infections
• Bone and joint infections
• Uncomplicated gonorrhea
• Early Lyme disease
• Septicemia
• Meningitis It is also used as a switch therapy from an injectable to an oral antibiotic.

Pharmacology

• Cefuroxime: A bactericidal, second-generation cephalosporin antibiotic. It works by interfering with the transpeptidation process, which inhibits bacterial cell wall synthesis. It is effective against a wide range of gram-positive and gram-negative bacteria, including many beta-lactamase producing strains.
• Clavulanic acid: A beta-lactamase inhibitor that binds irreversibly to beta-lactamase enzymes, inactivating them. It protects Cefuroxime from degradation by these enzymes, making the combination effective against resistant bacteria.

Dosage & Administration

• Adolescents and Adults (13 years and older):
  • Pharyngitis/Tonsillitis: 250 mg twice daily (b.i.d.) for 5-10 days.
  • Acute bacterial maxillary sinusitis: 250 mg b.i.d. for 10 days.
  • Acute bacterial exacerbation of chronic bronchitis: 250-500 mg b.i.d. for 10 days.
  • Uncomplicated gonorrhea: 1000 mg as a single dose.
  • Early Lyme disease: 500 mg b.i.d. for 20 days.
• Pediatric Patients (3 months to 12 years): Doses are based on weight.
  • Pharyngitis/Tonsillitis: 20 mg/kg/day b.i.d. for 5-10 days.
  • Acute otitis media, acute bacterial maxillary sinusitis, impetigo: 30 mg/kg/day b.i.d. for 10 days. The tablet may be taken with or without food.

Interaction

• Probenecid: Concomitant use increases the concentration of Cefuroxime in the blood.
• Drugs that reduce gastric acidity: These may lower the bioavailability of Cefuroxime.

Contraindications

Fuclav is contraindicated in patients with a known allergy to cephalosporin antibiotics or in patients with Pseudomembranous Colitis.

Side Effects

Fuclav is generally well-tolerated. Common side effects include nausea, vomiting, diarrhea, and abdominal discomfort. Prolonged use may lead to overgrowth of non-susceptible microorganisms. Rarely, side effects like renal dysfunction, anaphylaxis, angioedema, rash, and urticaria may occur.

Pregnancy & Lactation

• Pregnancy: While antibiotics should be avoided in the first trimester if possible, Fuclav is considered safe for use in later pregnancy to treat bacterial infections.
• Lactation: It is excreted in small quantities into breast milk. The possibility of sensitizing the infant should be considered.

Precautions & Warnings

Use with care in patients receiving concurrent treatment with potent diuretics and in those with a history of colitis.

Quick Tips

• Take the full prescribed course of treatment even if you feel better to prevent the infection from returning.
• Taking the medicine with food can help prevent an upset stomach.
• Diarrhea is a possible side effect; probiotics may help. Consult a doctor if you experience bloody stools or abdominal cramps.
• Stop taking the medicine and seek immediate medical attention if you experience an itchy rash, swelling of the face, throat or tongue, or breathing difficulties.
• Do not use leftover medication for future infections. Always consult a doctor before taking any antibiotic.

Therapeutic Class

Fuclav is a combination of Cefuroxime and Clavulanic Acid.

Storage Conditions

Store in a cool, dry place (below 30°C), away from light and moisture. Keep out of the reach of children.