Ariprex Tablet

Ariprex tablet contains Aripiprazole as the active ingredient. It is an atypical antipsychotic medication. In Bangladesh, Ariprex is available in 2 mg, 10 mg, and 15 mg strengths and is manufactured by Square Pharmaceuticals PLC.

Indications: Ariprex is indicated for the treatment of:

• Schizophrenia in adults and adolescents (13-17 years).
• Bipolar disorder (manic and mixed episodes) in adults and children (10-17 years).
• Adjunctive treatment of major depressive disorder in adults.
• Irritability associated with autistic disorder in children and adolescents (6-17 years).
• Agitation associated with schizophrenia or bipolar mania.

Dosage and Administration: The dosage varies depending on the condition being treated, the patient's age, and individual response. It is crucial to follow your doctor's instructions. General dosage guidelines:

• Schizophrenia (Adults): Initial dose is usually 10-15 mg once daily. The recommended dose is also in the range of 10-15 mg/day, with a maximum dose of 30 mg/day.
• Schizophrenia (Adolescents 13-17 years): Initial dose is typically 2 mg/day, increasing to a recommended dose of 10 mg/day, with a maximum of 30 mg/day.
• Bipolar Mania (Adults): Initial dose for monotherapy is usually 15 mg once daily, with a maximum of 30 mg/day. As an adjunct to lithium or valproate, the initial dose is 10-15 mg/day, with a maximum of 30 mg/day.
• Bipolar Mania (Children and Adolescents 10-17 years): Initial dose is 2 mg/day, increasing to a recommended dose of 10 mg/day, with a maximum of 30 mg/day.
• Adjunctive Treatment of Major Depressive Disorder (Adults): Initial dose is 2-5 mg/day, with a recommended dose of 5-10 mg/day and a maximum of 15 mg/day.
• Irritability Associated with Autistic Disorder (Children and Adolescents 6-17 years): Initial dose is 2 mg/day, with a recommended dose of 5-10 mg/day and a maximum of 15 mg/day.

Ariprex tablets are usually taken once daily, without regard to meals.

Side Effects: Common side effects may include:

• Nausea and vomiting
• Constipation
• Headache
• Dizziness
• Sleepiness (somnolence)
• Insomnia (difficulty sleeping)
• Anxiety
• Restlessness
• Akathisia (inability to stay still)
• Tremor
• Fatigue
• Blurred vision
• Increased saliva production
• Indigestion
• Abdominal pain
• Increased or decreased appetite
• Weight gain

Less common but potentially serious side effects can occur. It is important to report any unusual symptoms to your doctor.

Precautions:

• Use with caution in patients with cardiovascular or cerebrovascular disease, conditions predisposing to hypotension, history of seizures, diabetes, and elderly patients with dementia-related psychosis.
• Aripiprazole may cause drowsiness and dizziness, impairing the ability to drive or operate machinery.
• Avoid alcohol consumption while taking Ariprex.
• Inform your doctor if you have a history of suicidal thoughts or behavior.
• Be aware of potential metabolic changes, including hyperglycemia, dyslipidemia, and weight gain.
• Inform your doctor if you are pregnant or breastfeeding.

Contraindications: Ariprex is contraindicated in patients with known hypersensitivity to aripiprazole or any of its components.

Drug Interactions: Ariprex can interact with various medications. Inform your doctor about all the medicines you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Significant interactions can occur with drugs that affect CYP2D6 and CYP3A4 enzymes.

Storage: Store below 30°C, away from light and moisture. Keep out of reach of children.

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.