Indications
Amaryl 3 mg (glimepiride) is indicated for the management of type 2 diabetes mellitus, particularly when diet, exercise, and weight reduction alone are insufficient. It may be used as monotherapy or combined with insulin/metformin.

Pharmacology
Glimepiride stimulates insulin release from pancreatic β-cells by closing ATP-dependent potassium channels. It enhances peripheral insulin sensitivity and reduces hepatic glucose production.

Dosage & Administration

• Initial dose: 1–2 mg once daily with breakfast or first main meal.

• Maintenance: Adjust by 1–2 mg increments every 1–2 weeks based on glycemic response.

• Maximum dose: 8 mg daily.

• Amaryl 3 mg: For patients requiring higher doses after titration.
  Individualize dosing; monitor blood glucose regularly.

Interaction

• Contraindicated: Bosentan.

• Increased hypoglycemia risk: Insulin, other sulfonylureas, MAO inhibitors, NSAIDs, salicylates.

• Reduced efficacy: Thiazides, corticosteroids, thyroid hormones, sympathomimetics.

• Variable effects: Warfarin (monitor INR).

Contraindications

• Hypersensitivity to sulfonylureas/sulfonamides.

• Type 1 diabetes, diabetic ketoacidosis.

• Severe renal/hepatic impairment.

• Pregnancy/lactation.

Side Effects

• Common: Hypoglycemia, dizziness, headache, nausea.

• Serious: Hepatic dysfunction, hemolytic anemia, allergic skin reactions.

Pregnancy & Lactation
Contraindicated. May cause fetal harm. Discontinue if pregnancy occurs.

Precautions

• Monitor liver/kidney function.

• Avoid alcohol (disulfiram-like reaction).

• Risk of hypoglycemia in elderly/malnourished.

Overdose Effects
Severe hypoglycemia (sweating, tremors, coma). Treat with glucose IV.

Therapeutic Class
Sulfonylurea antidiabetic

Storage Conditions
Below 25°C in dry place. Protect from light. Keep away from children.

Composition

• Active: Glimepiride 3 mg

• Molecular Formula: C₂₄H₃₄N₄O₅S