A Flox Powder For Suspension - (125mg/5ml)

Presentation:

• Each 5 ml of reconstituted suspension contains Flucloxacillin Sodium equivalent to 125 mg of Flucloxacillin.  
• Available in bottles containing powder for reconstitution to [mention typical bottle size based on search results, e.g., 100 ml] suspension.  

Indications:

• Treatment of infections due to Gram-positive organisms, including penicillinase-producing staphylococci.  
• Skin and soft tissue infections: boils, abscesses, carbuncles, infected skin conditions (e.g., ulcer, eczema, acne, furunculosis, cellulitis, infected wounds, infected burns,otitis media and externa, impetigo).  
• Respiratory tract infections: pneumonia, lung abscess, empyema, sinusitis, pharyngitis, tonsillitis, quinsy.  
• Other infections:osteomyelitis, enteritis, endocarditis, urinary tract infection, meningitis, septicaemia caused by A Flox-sensitive organisms.  
• Prophylactic agent during major surgical procedures where appropriate (e.g., cardiothoracic and orthopedic surgery).  

Dosage and Administration:

• Oral doses should be administered 1 hour before a meal.  
• Dosage depends on the age, weight, renal function of the patient, as well as the severity of the infection.
• Adults:250 mg four times daily. Dosage may be doubled in severe infections. In osteomyelitis and endocarditis, up to 8 gm daily is used in 6-8 hourly divided doses.
• Children (2-10 years):Half of the adult dose. 
• Children (Under 2 years): Quarter of the adult dose.
• For severe renal failure (creatinine clearance <10 ml/min), dose reduction or extension of the dosing interval may be considered.

Pharmacology:

• Flucloxacillin is a bactericidal antibiotic that inhibits the formation of the bacterial cell wall. It is an isoxazolyl penicillin, combining resistance to hydrolysis by penicillinase, stability in gastric acid, and activity against Gram-positive bacteria.

Side Effects:

• Common side effects affecting the gastrointestinal tract include nausea, vomiting, diarrhoea, dyspepsia, and other minor gastrointestinal disturbances.
• Reports have indicated occurrences of rashes, urticaria, purpura, fever, interstitial nephritis, hepatitis, and cholestatic jaundice.

Precautions:  

• A Flox should be used with caution in patients with evidence of hepatic dysfunction.
• Caution should also be exercised in the treatment of patients with an allergic diathesis.  
• Use with caution in severe renal failure; dose adjustment may be needed.

Contraindications:

• Flucloxacillin is contraindicated in penicillin-hypersensitive patients.

Pregnancy & Lactation:

• A Flox is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects.
• Caution should be exercised during breastfeeding as Flucloxacillin can be excreted in breast milk.  

Storage:

• Keep in a dry place away from light and heat.
• Keep out of the reach of children.
• Reconstituted solution should be stored in a refrigerator (2°C - 8°C) and used within 7 days.

Therapeutic Class:

• Penicillinase-resistant penicillins.

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.