Pharmacology

Luliconazole is a topical antifungal agent from the azole group. It works by inhibiting the enzyme lanosterol demethylase, which blocks the synthesis of ergosterol. Ergosterol is a crucial component of the fungal cell membrane. By disrupting its synthesis, Luliconazole exerts a strong fungicidal effect against dermatophytes, Candida albicans, Malassezia spp, and others.

Dosage & Administration

• Adults & Geriatric:
  • Interdigital tinea pedis: Apply to the affected area and a 1-inch surrounding area once daily for two weeks.
  • Tinea cruris and Tinea corporis: Apply to the affected area and a 1-inch surrounding area once daily for one week.
• Pediatric: The safety and effectiveness of this cream have not been established in children.

Contraindications

Luliconazole cream is contraindicated in patients with a history of hypersensitivity to Luliconazole.

Side Effects

• Common: Contact dermatitis and cellulitis may occur.
• Rare: Application site reactions were observed in less than 1% of patients in clinical trials.

Pregnancy & Lactation

• Pregnancy: There are no adequate and well-controlled studies of Luliconazole cream in pregnant women. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Lactation: It is not known whether Luliconazole is excreted in human milk. Caution should be exercised when the cream is applied to breastfeeding women.

Precautions & Warnings

• If an unusual allergic reaction occurs, discontinue treatment and institute appropriate therapy.
• Luliconazole cream is for topical use only. It is not intended for ophthalmic (eye), oral, or intravaginal use.

Therapeutic Class

Luliconazole is classified as a miscellaneous topical agent.

Storage Conditions

Do not store above 30°C. Keep away from light and out of the reach of children.