Indications

Ebasten (Ebastine) is a non-sedating antihistamine used for the symptomatic treatment of:

• Seasonal and Perennial Allergic Rhinitis: To relieve allergy symptoms like sneezing, itchy nose, and watery eyes.
• Chronic Idiopathic Urticaria: To treat hives and associated itching.

Pharmacology

Ebastine is a long-acting, selective H1-histamine receptor antagonist. When taken orally, it is rapidly absorbed and converted into its active metabolite, carebastine, which blocks peripheral histamine receptors responsible for allergic reactions.

Dosage & Administration

• Tablet:
  • Adults (>12 years): 10 mg (one tablet) once daily.
  • Children (6-12 years): 5 mg (half a tablet) once daily.
• Syrup:
  • Children (2-5 years): 2.5 ml once daily (can be increased to 5 ml for severe perennial allergic rhinitis).
  • Children (6-12 years): 5 ml once daily (can be increased to 10 ml for severe perennial allergic rhinitis). Ebasten can be taken with or without food.

Interaction

• Ketoconazole or Erythromycin: Taking Ebasten with these medications can increase its plasma levels and potentially prolong the QTc interval.
• Alcohol or Diazepam: Ebasten may enhance their sedative effects.
• Other Drugs: It does not have significant interactions with theophylline, warfarin, cimetidine, or other common drugs.

Contraindications

Do not use Ebasten if you have a known hypersensitivity to Ebastine or any of its ingredients.

Side Effects

The most common side effects are headache, dry mouth, and drowsiness. Less common side effects include abdominal pain, nausea, and insomnia.

Overdose Effects

In cases of overdose (up to 100 mg), no clinically significant signs or symptoms were observed. There is no specific antidote. Treatment involves supportive measures, such as gastric lavage and monitoring vital signs.

Therapeutic Class

Ebasten is classified as a Non-sedating antihistamine.

Storage Conditions

Store in a cool, dry place below 30°C, protected from light. Keep out of reach of children.