Cefpodoxime & Clavulanic Acid

Pharmacology

• Cefpodoxime: A 3rd-generation cephalosporin active against Gram-positive and Gram-negative bacteria.

• Clavulanic Acid: A beta-lactamase inhibitor that prevents bacteria from inactivating Cefpodoxime.

Indications & Dosage

Note: Take strictly as prescribed by a registered physician.

• Adults & Children (≥12 years):

  • Acute Bronchitis Exacerbation / Sinusitis: 1 tablet every 12 hours for 10 days.

  • Community-Acquired Pneumonia: 1 tablet every 12 hours for 14 days.

  • Pharyngitis / Tonsillitis: ½ tablet every 12 hours for 5–10 days.

  • Skin & Soft Tissue Infections: 2 tablets every 12 hours for 7–14 days.

  • Urinary Tract Infections (UTI): ½ tablet every 12 hours for 7 days.

  • Uncomplicated Gonorrhea: Single dose.

• Children (2 months to 12 years): $10\text{ mg/kg/day}$ divided into two doses (every 12 hours).

Key Precautions & Warnings

• Contraindications: Do not use if allergic to cephalosporins.

• Drug Interactions: Antacids and H2 blockers reduce peak Cefpodoxime absorption. Exercise caution if taking concurrent diuretics.

• Side Effects: Generally well tolerated; common issues include diarrhea, vomiting, and abdominal pain.

• Pregnancy & Nursing: FDA Category B. Use during pregnancy only if clearly needed. Cefpodoxime passes into breast milk; caution is advised.

• Storage: Keep in a dry, cool place away from direct light, heat, and children.