ATOZ® Senior Multivitamin - Product Monograph

Comprehensive nutritional support for adults ≥45 years

Indications

• Prevention and treatment of vitamin/mineral deficiencies in adults ≥45 years

• Nutritional support for age-related increased micronutrient demands
  (Use under physician's guidance)

Composition

Vitamins

Minerals & Antioxidants

*RDA based on USDA 2020-2025 guidelines for seniors

Pharmacology

Age-Targeted Formulation Rationale:

1. ↑ B₁₂ (25mcg): Compensates for age-related ↓ absorption (atrophic gastritis)

2. ↑ Vitamin D (400IU): Addresses ↓ cutaneous synthesis and ↓ renal activation

3. Antioxidant Blend: Counters oxidative stress acceleration in aging

4. Bone Support: Calcium + Vitamin D synergy for osteoporosis prevention

Dosage & Administration

• Adults ≥45 years: 1 tablet daily with food

• Critical Timing: Morning meal (optimizes fat-soluble vitamin absorption)

Do not exceed recommended dose - synergistic overdose risk with other supplements
(Follow physician's advice)

Contraindications

• Hypersensitivity to any component

• Concurrent therapeutic vitamin A supplementation (>10,000 IU/day)

• Hypercalcemia (vitamin D sensitivity)

Precautions & Warnings

1. Vitamin A Toxicity:

   • Long-term use may ↑ osteoporosis risk in postmenopausal women

   • Avoid concurrent liver/organ meat consumption

2. Drug Interactions:

   Concomitant Drug	Risk
   Warfarin	Vitamin K antagonism → ↓ INR stability
   Levothyroxine	Calcium/zinc ↓ absorption → separate by 4h
   Tetracyclines	Divalent cations ↓ antibiotic absorption

3. Renal Impairment:

   • Avoid in eGFR <30 mL/min (zinc/magnesium accumulation risk)

Side Effects

Rare (<0.1%):

• GI disturbances (nausea, diarrhea - vitamin C/E related)

• Allergic reactions (folic acid sensitization)

• Dark stools (iron-free; likely selenium/copper interaction)

Special Populations

• Pregnancy/Lactation: Not indicated for this demographic (formulated for ≥45y)

• Hepatic Impairment: Avoid (vitamin A storage risk)

Overdose Management

Acute Symptoms:

• Vitamin A: Nausea, blurred vision, headache

• Vitamin D: Hypercalcemia (confusion, polyuria)

• Zinc: Metallic taste, epigastric pain

Treatment:

1. Activated charcoal if <2h post-ingestion

2. IV hydration + electrolyte monitoring

3. Serum vitamin level quantification

Therapeutic Class

Geriatric Multivitamin/Mineral Supplement

Storage

• Conditions: 15-30°C • Protect from light/humidity

• Stability: 36 months • Keep bottle tightly sealed