Alice Tablet (Ivermectin): Comprehensive Antiparasitic & Anthelmintic Treatment

Alice contains Ivermectin, a high-affinity anthelmintic medication. It works by selectively binding to glutamate-gated chloride ion channels found in invertebrate nerve and muscle cells. This increases cell membrane permeability, leading to hyperpolarization, paralysis, and the ultimate death of the parasite.

📋 Indications: Target Parasites & Infections

Alice is indicated for the treatment of various parasitic infestations:

• Strongyloidiasis: Intestinal tract infections caused by the nematode parasite Strongyloides stercoralis.

• Onchocerciasis (River Blindness): Systemic infections caused by the parasite Onchocerca volvulus.

• Filariasis: Broad-spectrum treatment for lymphatic parasitic worm infestations.

• Ectoparasitic Infestations: Highly effective against Scabies and Head lice.

🥄 Dosage and Administration Guidelines

• Crucial Instruction: For parasitic infections, tablets must be taken on an empty stomach with water.

• Pediatric Warning: Safety and efficacy have not been established for children weighing less than 15 kg.

1. Strongyloidiasis (Single Oral Dose)

Designed to provide roughly 200 mcg/kg of body weight:

• 15–24 kg: 3 mg

• 25–35 kg: 6 mg

• 36–50 kg: 9 mg

• 51–65 kg: 12 mg

• 66–79 kg: 15 mg

• >80 kg: 200 mcg/kg

• Note: Follow-up stool examinations should be conducted to verify complete eradication.

2. Onchocerciasis (Single Oral Dose)

Designed to provide roughly 150 mcg/kg of body weight, typically repeated every 12 months (or as short as 3 months for individual retreatment):

• 15–25 kg: 3 mg

• 26–44 kg: 6 mg

• 45–64 kg: 9 mg

• 65–84 kg: 12 mg

• >85 kg: 150 mcg/kg

3. Prophylaxis & Alternative Regimens

• Prophylaxis Dose: Take the weight-appropriate single dose on Day 1 and repeat the exact same dose on Day 7.

• COVID-19 Positive Regimen (As detailed in text): 2 tablets of Ivermectin 6 mg (12 mg total) once daily for 5 days.

⚠️ Safety Warnings & Serious Precautions

• Mazzotti Reaction: Patients treated for onchocerciasis may experience mild to severe allergic and inflammatory responses (postural hypotension, fever, rash, lymph node tenderness) due to the rapid death of the microfilariae.

• Loa loa Co-infection: Heavily co-infected patients run a rare risk of developing serious or fatal encephalopathy (brain dysfunction), presenting as confusion, lethargy, back pain, or difficulty walking.

• Blood Thinners: Rare post-marketing reports indicate an increased INR when co-administered with Warfarin. Monitor bleeding times closely.

🤰 Pregnancy & Lactation

• Pregnancy: Classified as Category C. Safety has not been firmly established, so Alice should not be used during pregnancy.

• Lactation: Excreted in low concentrations in human milk. Nursing mothers should only take this if the risk of delaying treatment outweighs the potential risk to the newborn.

📦 Storage Conditions

• Store in a dry place below 30°C.

• Protect from direct light and keep securely out of the reach of children.