Desotem (Desloratadine): A Non-Sedating Antihistamine

Desotem contains Desloratadine, a non-sedating, long-acting histamine antagonist. It is the major active metabolite of loratadine. Desloratadine works by selectively blocking H1-receptors and inhibiting histamine release from mast cells. It is indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis and chronic idiopathic urticaria.

How Desotem Works (Pharmacology)

Desloratadine's mechanism is based on blocking histamine and its release:

• H1-Receptor Antagonist: It acts as a selective antagonist of the H1-histamine receptor, preventing histamine from causing allergic symptoms like sneezing, itching, and congestion.
• Inhibits Histamine Release: It also helps to prevent the release of histamine from mast cells, which are key cells in the allergic response.

Key Indications & Benefits

Desotem is indicated for the relief of symptoms associated with:

• Seasonal and perennial allergic rhinitis: Such as sneezing, nasal discharge, itching, congestion, and ocular symptoms.
• Chronic idiopathic urticaria: Such as itching and the reduction of hives (size and number).

Dosage & Administration

Desotem is available in pediatric drops, syrup, and tablets. The dosage varies by age:

• Adults and Children 12+ years (Tablet/Syrup): 10 ml syrup or 1 tablet (5 mg) once daily.
• Children 6-11 years (Syrup): 5 ml once daily.
• Children 1-5 years (Syrup/Drops): 2.5 ml once daily.
• Children 6-11 months (Syrup/Drops): 2 ml once daily.
• Patients with liver or renal impairment: A reduced dose of one 5 mg tablet every other day is recommended.

Important Considerations & Warnings

It is crucial to discuss your full medical history with your doctor before taking Desotem.

Contraindications:

• Hypersensitivity to desloratadine, loratadine, or any of the ingredients.

Side Effects:

• Less common: Headache, nausea, fatigue, dizziness, pharyngitis, dyspepsia, and myalgia.

Pregnancy & Lactation:

• Pregnancy Category C: The safe use during pregnancy has not been established. Use only if clearly indicated.
• Lactation: Desloratadine passes into breast milk, so a decision must be made to either discontinue nursing or discontinue the drug.

Precautions & Warnings:

• Use with caution in patients with a history of seizures.
• Dosage adjustment is recommended for adult patients with liver or renal impairment.

Drug Interactions:

• No clinically relevant drug interactions have been reported.

Overdose Effects

• No clinically relevant adverse effects have been reported from overdose.

Storage Conditions

Store in a cool, dry place below 30°C, protected from light. Keep out of the reach of children.