Rupa 10

Presentation:

• Each tablet contains 10 mg of Rupatadine (as Rupatadine Fumarate).
• Available in strips of [mention typical strip size, e.g., 10 tablets].

Indications:

• Symptomatic treatment of allergic rhinitis (seasonal and perennial).
• Symptomatic treatment of chronic idiopathic urticaria.

Dosage and Administration:

• Adults and adolescents (over 12 years): The recommended dose is 10 mg once daily, with or without food.

Pharmacology:

• Rupatadine is a second-generation antihistamine. It is a long-acting, non-sedating antagonist of the H1-histamine receptor and also has antagonist activity against the platelet-activating factor (PAF). By inhibiting histamine and PAF, rupatadine helps to reduce the symptoms of allergic reactions.

Side Effects:

• Common side effects may include:
  • Headache
  • Somnolence (drowsiness)
  • Fatigue
  • Dizziness
  • Dry mouth
• Uncommon side effects may include increased appetite, irritability, difficulty concentrating, nausea, diarrhoea, abdominal pain, rash, and back pain.

Precautions:

• Use with caution in patients with known prolongation of the QTc interval, clinically significant cardiovascular diseases, uncorrected hypokalemia, and uncorrected hypomagnesemia.
• Caution should be exercised when rupatadine is co-administered with inhibitors of the CYP3A4 isoenzyme (e.g., ketoconazole, erythromycin) or inhibitors of P-glycoprotein (e.g., cyclosporine, verapamil) as this may increase systemic exposure to rupatadine.
• Avoid the use of rupatadine with grapefruit juice as it may increase the systemic exposure to rupatadine.
• The safety and efficacy of rupatadine in children under 12 years have not been established.

Pregnancy & Lactation:

• There are limited data on the use of rupatadine in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryonal/foetal development, parturition or postnataldevelopment. As a precautionary measure, it is preferable to avoid the use of rupatadine during pregnancy unless clearly needed.   
• Rupatadine is excreted in animal milk. It is unknown if rupatadine is excreted in human milk. A decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importanceof the drug to the mother.  

Storage:

• Store below 30°C, protected from light and moisture.
• Keep out of the reach of children.

Therapeutic Class:

• Antihistamines.

Important Note: This information is for general knowledge and informational purposes only and does not substitute professional medical advice. Always consult your doctor or pharmacist for specific instructions and guidance regarding your medication. They can assess your individual medical condition and provide the most appropriate advice.